NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following statins must be taken in the evening?

Rosuvastatin
Atorvastatin
Simvastatin (Zocor)
Pitavastatin

The correct answer is: Simvastatin (Zocor)

Statin medications are used to help lower cholesterol levels in the body. While different statins can be taken at different times of the day, simvastatin (Zocor) must be taken in the evening. This is because simvastatin has a half-life of about 2 to 4 hours, which means it is eliminated from the body quite quickly. Therefore, taking it in the evening allows for the medication to be most effective at reducing cholesterol levels during the time when the body produces the most cholesterol, which is during sleep. Therefore, it is important to take simvastatin in the evening for maximum effectiveness. The other options, including rosuvastatin, atorvastatin, and pitavastatin, can be taken at any time of the day.