NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is an appropriate drug-drug interaction consideration with warfarin?

Increase dose of warfarin when starting amiodarone
Decrease dose of warfarin by 30-50% when starting amiodarone
Avoid aspirin with warfarin at all costs
There are no significant drug interactions with warfarin

The correct answer is: Decrease dose of warfarin by 30-50% when starting amiodarone

Warfarin is a blood thinner used to prevent and treat blood clots, whereas amiodarone is used to treat heart rhythm problems. These two medications can have a dangerous interaction, leading to increased risk of bleeding. Therefore, it is important to closely monitor warfarin levels and decrease the dose by 30-50% when starting amiodarone to prevent any potential adverse effects. Option A is incorrect because increasing the dose of warfarin could result in an elevated INR and increase the risk of bleeding. Option C is incorrect because while it is recommended to avoid combining aspirin with warfarin, it is not an absolute contraindication. Option D is also incorrect because warfarin has many potential drug interactions that should be carefully considered by a healthcare provider before prescribing.