NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following drugs used for Hepatitis C treatment should not be used with amiodarone?

Ledipasvir
Sofosbuvir
Pibrentasvir
Glecaprevir

The correct answer is: Sofosbuvir

Amiodarone is known to increase the risk of bradycardia when used together with sofosbuvir, which is a drug commonly used for Hepatitis C treatment. Combining these two medications can lead to serious cardiac complications, making it important to avoid their concomitant use. The other options listed, including ledipasvir, pibrentasvir, and glecaprevir, do not have the same known interactions with amiodarone as sofosbuvir does.