NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication can lower testosterone levels?

  1. Ibuprofen

  2. Cimetidine

  3. Levothyroxine

  4. Aspirin

The correct answer is: Cimetidine

Cimetidine can lower testosterone levels by inhibiting the enzyme responsible for converting testosterone to dihydrotestosterone. This leads to an increase in circulating testosterone levels and a decrease in dihydrotestosterone levels. Ibuprofen, levothyroxine, and aspirin do not have an impact on testosterone levels.