NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which drug class is included in the HIV treatment during pregnancy?

NRTIs
NNRTIs
INSTIs
Boosted PIs

The correct answer is: INSTIs

During pregnancy, Integrase Strand Transfer Inhibitors (INSTIs) are often included in HIV treatment regimens. This drug class is preferred due to its efficacy and safety profile for both the mother and the developing fetus. INSTIs work by blocking the enzyme integrase, which the HIV virus needs to replicate. This helps in reducing the viral load in the mother and decreasing the risk of vertical transmission to the fetus. Therefore, INSTIs are a crucial component of HIV treatment during pregnancy. While Nucleoside Reverse Transcriptase Inhibitors (NRTIs) are commonly used in HIV treatment, INSTIs are usually preferred during pregnancy due to their safety and efficacy profile. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and Boosted Protease Inhibitors (PIs) may have more adverse effects or limitations during pregnancy compared to INSTIs.