NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which antibiotics are cycled 28 days on and 28 days off for CF?

Aztreonam and tobramycin
Pancrealipase
Dornase alfa
Ivacaftor

The correct answer is: Aztreonam and tobramycin

In the treatment of cystic fibrosis (CF), antibiotics are often used to manage lung infections. The antibiotics aztreonam and tobramycin are specifically cycled in a 28 days on and 28 days off schedule for CF patients. This cyclic dosing regimen helps to minimize the development of antibiotic resistance while still effectively treating the lung infections commonly seen in CF patients. On the other hand, the other options listed do not follow this specific treatment regimen for CF. Pancrealipase is an enzyme supplement used to aid in the digestion of fats in individuals with pancreatic insufficiency. Dornase alfa is a mucolytic agent used to reduce the viscosity of mucus in the lungs of CF patients. Ivacaftor is a CFTR modulator used to treat certain genetic mutations in CF. None of these options are cycled 28 days on and 28 days off like aztreonam and tobramycin.