NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which antibiotic is known for its atypical coverage?

Azithromycin
Doxycycline
Quinolones
Cefepime

The correct answer is: Azithromycin

Azithromycin is known for its atypical coverage due to its mechanism of action, which inhibits protein synthesis in bacteria. This allows it to effectively treat a wide range of Gram-positive and Gram-negative organisms, including those that are more resistant to other antibiotics. In contrast, doxycycline (B), quinolones (C), and cefepime (D) have different mechanisms of action that limit their effectiveness against atypical bacteria. Doxycycline primarily targets bacteria that grow inside of cells, while quinolones inhibit DNA replication and cefepime blocks cell wall synthesis. Therefore, these antibiotics may not be as effective in treating atypical infections compared to azithromycin.