NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What side effect is common to most drugs in the PI class?

Increased SCr
Metabolic abnormalities
Neural tube defects
Hyperpigmentation of palms/soles

The correct answer is: Metabolic abnormalities

Most drugs in the PI (protease inhibitor) class are associated with metabolic abnormalities as a common side effect. This class of antiretroviral medications commonly causes metabolic issues such as dyslipidemia (abnormal levels of lipids in the blood), insulin resistance, and changes in body fat distribution (lipodystrophy). These metabolic abnormalities can increase the risk of cardiovascular disease and other complications in patients taking PI drugs for the management of HIV infection. Options A, C, and D are not typically associated with drugs in the PI class. Increased SCr (serum creatinine) is more commonly seen with medications that have effects on renal function, neural tube defects are not a known side effect of PI drugs, and hyperpigmentation of palms/soles is not a common side effect associated with this drug class.