NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What should not be used with Simvastatin or Lovastatin?

Grapefruit
Ezetimibe
PCSK9 inhibitors
Bile acid sequestrates

The correct answer is: Grapefruit

Grapefruit should not be used with Simvastatin or Lovastatin because it can increase the risk of side effects such as muscle pain and liver damage. Bile acid sequestrants (D) can also interact with Simvastatin and Lovastatin, reducing their effectiveness. Ezetimibe (B) and PCSK9 inhibitors (C) are not known to interact with these medications.