NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the lifetime maximum cumulative dose of Doxorubicin to avoid cardiotoxicity?

  1. 250-350 mg/m2

  2. 450-550 mg/m2

  3. 650-750 mg/m2

  4. 850-950 mg/m2

The correct answer is: 450-550 mg/m2

The correct answer is B, 450-550 mg/m2. This range is the lifetime maximum cumulative dose of Doxorubicin recommended to avoid cardiotoxicity. Exceeding this cumulative dose can increase the risk of developing cardiomyopathy and congestive heart failure. It is crucial for healthcare providers to closely monitor the cumulative dose of Doxorubicin administered to patients to minimize the potential for cardiotoxicity. The other options are incorrect because they suggest higher cumulative doses of Doxorubicin that could significantly increase the risk of cardiotoxicity and other adverse effects.

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