NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the antidote for warfarin?

Vitamin K
Protamine sulfate
Andexanet alfa
Idarucizumab

The correct answer is: Vitamin K

Vitamin K is the antidote for warfarin. Warfarin is a vitamin K antagonist that interferes with the normal clotting of blood by inhibiting the activation of vitamin K-dependent clotting factors. Therefore, administering vitamin K can help reverse the effects of warfarin by promoting the production of these clotting factors. Options B, C, and D are not the antidotes for warfarin but rather antidotes for other anticoagulants. Protamine sulfate is used as an antidote for heparin, andexanet alfa is used as an antidote for factor Xa inhibitors such as apixaban and rivaroxaban, and idarucizumab is used as an antidote for dabigatran.