NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a unique side effect of Spironolactone among potassium-sparing diuretics?

Nausea
Gynecomastia
Headache
Insomnia

The correct answer is: Gynecomastia

Among the potassium-sparing diuretics, Spironolactone is unique in causing gynecomastia as a side effect. This is because Spironolactone is an aldosterone antagonist that can lead to anti-androgenic effects, resulting in gynecomastia in men and breast tenderness in women. Nausea, headache, and insomnia are not typically associated with Spironolactone use.