NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a significant risk when using Anastrozole or Letrozole, compared to SERMs?

  1. Lower risk of osteoporosis

  2. Higher risk of osteoporosis

  3. Lower risk of cardiovascular disease

  4. No risk of thromboembolic events

The correct answer is: Higher risk of osteoporosis

When using Anastrozole or Letrozole, compared to SERMs, there is a higher risk of osteoporosis because these drugs, known as aromatase inhibitors, decrease estrogen levels in the body which can result in bone loss. SERMs, on the other hand, have been shown to have a protective effect on bone health. The other options are incorrect because they do not address the potential side effects of Anastrozole and Letrozole. While these drugs may have lower risks of cardiovascular disease and no risk of thromboembolic events, those benefits do not apply to the increased risk of osteoporosis.

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