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What is a major contraindication for the use of RANKL Inhibitor: Denosumab?
Hypertension
Hypocalcemia
Diabetes
Renal impairment
The correct answer is: Hypocalcemia
A major contraindication for the use of RANKL inhibitor Denosumab is hypocalcemia. This is because Denosumab can decrease calcium levels in the blood, which can lead to serious complications such as hypocalcemia. Therefore, patients with a history of hypocalcemia should not take this medication. The other options, hypertension, diabetes and renal impairment, are not major contraindications for the use of RANKL inhibitor: Denosumab. While these conditions may require caution and monitoring, they do not completely prevent the use of the medication. It is important to consult with a healthcare provider before taking any medication and to discuss any pre-existing conditions that may affect its use.