NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What condition prohibits the use of Primaquine for malaria prophylaxis?

  1. Pregnancy

  2. Diabetes

  3. G6PD deficiency

  4. Psychiatric conditions

The correct answer is: G6PD deficiency

G6PD deficiency is a genetic disorder that affects red blood cells and causes them to break down when exposed to certain triggers. Primaquine can cause these triggers in people with G6PD deficiency, hence it is not recommended for malaria prophylaxis. Pregnancy and psychiatric conditions are not absolute contraindications for the use of Primaquine, but it may need to be used with caution and under medical supervision. Diabetes does not prohibit the use of Primaquine, but it may also need to be used with caution in diabetic patients.