NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What common side effects do non-DHP CCBs have?

Edema, constipation
Cough, hyperkalemia
Dizziness, headache
Skeletal muscle effects

The correct answer is: Edema, constipation

Non-DHP (Dihydropyridine) calcium channel blockers (CCBs) commonly cause side effects such as edema and constipation. Edema can result from the vasodilatory effects of CCBs, leading to fluid retention in the extremities. Constipation, on the other hand, can occur due to the inhibition of calcium entry into smooth muscle cells in the gastrointestinal tract, resulting in decreased motility and constipation. Options B, C, and D are incorrect: - Option B mentions cough and hyperkalemia, which are not commonly associated with non-DHP CCBs. - Option C lists dizziness and headache, which are general side effects seen with many medications but are not specific to non-DHP CCBs. - Option D refers to skeletal muscle effects, which are more commonly associated with statins or fibrates rather than non-DHP CCBs.