NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Vortioxetine's dose should be decreased by what percentage when used with strong CYP2D6 inhibitors?

25%
50%
75%
100%

The correct answer is: 50%

When vortioxetine is used with strong CYP2D6 inhibitors, the dose should be decreased by 50%. This is because strong CYP2D6 inhibitors can increase the concentration of vortioxetine in the body, leading to a higher risk of adverse effects. Therefore, reducing the dose by 50% helps to maintain the therapeutic efficacy of the medication while minimizing the likelihood of side effects. Options A, C, and D are incorrect because they do not reflect the appropriate percentage by which the vortioxetine dose should be decreased when used with strong CYP2D6 inhibitors.