NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Voriconazole acts as what in relation to CYP enzymes?

CYP-2C19 substrate and inhibitor
CYP-2D6 inhibitor only
CYP-2C19 inducer
None of the above

The correct answer is: CYP-2C19 substrate and inhibitor

Voriconazole acts as a substrate and inhibitor of CYP-2C19 enzymes. This means that it is metabolized by the CYP-2C19 enzyme and can also inhibit the activity of this enzyme in the body. Option B is incorrect because Voriconazole not only inhibits CYP-2D6 but also is a substrate for CYP-2C19. Option C is incorrect as well because Voriconazole is not an inducer of CYP-2C19. Therefore, the correct answer is A.