NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For outpatient SSTIs, what is the first choice of treatment for impetigo?

  1. Topical Mupirocin

  2. Cephalexin

  3. SMX/TMP

  4. Vancomycin

The correct answer is: Topical Mupirocin

For outpatient SSTIs, the first choice of treatment for impetigo is topical Mupirocin. This is because Mupirocin is an effective antibiotic ointment that specifically targets and treats the bacteria causing impetigo, such as Staphylococcus aureus and Streptococcus pyogenes. Topical application of Mupirocin directly to the affected area helps eliminate the bacteria responsible for the infection, making it an appropriate and targeted therapy for impetigo. The other options listed are not the first choice for treating impetigo. Cephalexin is an oral antibiotic commonly used for other types of skin infections but is not the first-line treatment for impetigo. SMX/TMP and Vancomycin are usually reserved for more severe or resistant infections and are not typically recommended as initial therapy for impetigo. Therefore, in the case of outpatient impetigo treatment, topical Mupirocin stands out as the preferred choice.