NAPLEX Practice Exam 2026 – All-in-One Guide to Mastering the North American Pharmacist Licensure Examination!

Question: 1 / 1820

Which treatment is associated with an initial surge in testosterone, followed by a gradual reduction?

Aromatase inhibitors

Selective Estrogen Receptor Modulators

GnRH agonists

GnRH agonists are medications that initially stimulate the release of hormones, including testosterone. This initial surge in testosterone levels is known as a "testosterone flare." However, over time, continuous stimulation of the pituitary gland by GnRH agonists leads to desensitization and decreased release of gonadotropins, resulting in a reduction in testosterone levels.

Aromatase inhibitors and Selective Estrogen Receptor Degraders work by reducing the levels of estrogen, not testosterone. Selective Estrogen Receptor Modulators act as estrogen agonists or antagonists depending on the tissue, but they do not lead to an initial surge in testosterone followed by a gradual reduction like GnRH agonists do.

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Selective Estrogen Receptor Degraders

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